Transcriptional regulation of the MHC class II antigen presentation pathway

被引：136

作者：

Boss, JM ^{[1
]}

Jensen, PE

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(02)00015-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genes encoding the major components of the antigen processing and presentation pathway (MHC class II, invariant chain and HLA-DM) are regulated in a coordinate and concerted fashion by a conserved group of transcription factors. The identification and characterization of these transcription factors over the past few years has provided insight into how these important genes and the process of antigen presentation are regulated. Regulation of the antigen processing genes includes mechanisms involving the epigenetic modification of DNA sequences and chromatin, and the control of nuclear import of transcription factors.

引用

页码：105 / 111

页数：7

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