Origin, maturation and antigen presenting function of dendritic cells

被引：1123

作者：

Cella, M ^{[1
]}

Sallusto, F ^{[1
]}

Lanzavecchia, A ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(97)80153-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells are cells specialized for antigen capture, migration and T cell stimulation. Recent advances have been made in understanding their origin, their heterogeneity, the mechanism of antigen uptake, and the signals that induce their migration and maturation into immunostimulatory antigen-presenting cells. Dendritic cells represent the natural adjuvants for T cell responses and their therapeutic exploitation in the near future is foreseen.

引用

收藏

页码：10 / 16

页数：7

相关论文

共 75 条

[1] THYMIC DENDRITIC CELLS AND T-CELLS DEVELOP SIMULTANEOUSLY IN THE THYMUS FROM A COMMON PRECURSOR POPULATION [J].

ARDAVIN, C ;

WU, L ;

LI, CL ;

SHORTMAN, K .

NATURE, 1993, 362 (6422) :761-763

[2] New insights into the mobilization and phagocytic activity of dendritic cells [J].

Austyn, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1287-1292

[3] Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood [J].

Bender, A ;

Sapp, M ;

Schuler, G ;

Steinman, RM ;

Bhardwaj, N .

JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 196 (02) :121-135

[4] ANTIGEN PRESENTATION TO CYTOTOXIC T-LYMPHOCYTES IN-VIVO [J].

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (03) :639-641

[5] HUMAN EPIDERMAL LANGERHANS CELLS EXPRESS THE HIGH-AFFINITY RECEPTOR FOR IMMUNOGLOBULIN-E (FC-EPSILON-RI) [J].

BIEBER, T ;

DELASALLE, H ;

WOLLENBERG, A ;

HAKIMI, J ;

CHIZZONITE, R ;

RING, J ;

HANAU, D ;

DELASALLE, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (05) :1285-1290

[6] Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo [J].

Boczkowski, D ;

Nair, SK ;

Snyder, D ;

Gilboa, E .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :465-472

[7] ACTIVATION OF HUMAN DENDRITIC CELLS THROUGH CD40 CROSS-LINKING [J].

CAUX, C ;

MASSACRIER, C ;

VANBERVLIET, B ;

DUBOIS, B ;

VANKOOTEN, C ;

DURAND, I ;

BANCHEREAU, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1263-1272

[8] INTERLEUKIN-10 INHIBITS T-CELL ALLOREACTION INDUCED BY HUMAN DENDRITIC CELLS [J].

CAUX, C ;

MASSACRIER, C ;

VANBERVLIET, B ;

BARTHELEMY, C ;

LIU, YJ ;

BANCHEREAU, J .

INTERNATIONAL IMMUNOLOGY, 1994, 6 (08) :1177-1185

[9] CD34(+) hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha [J].

Caux, C ;

Vanbervliet, B ;

Massacrier, C ;

DezutterDambuyant, C ;

deSaintVis, B ;

Jacquet, C ;

Yoneda, K ;

Imamura, S ;

Schmitt, D ;

Banchereau, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :695-706

[10] GM-CSF AND TNF-ALPHA COOPERATE IN THE GENERATION OF DENDRITIC LANGERHANS CELLS [J].

CAUX, C ;

DEZUTTERDAMBUYANT, C ;

SCHMITT, D ;

BANCHEREAU, J .

NATURE, 1992, 360 (6401) :258-261

← 1 2 3 4 5 6 7 8 →