Endothelial calcium dynamics, connexin channels and blood-brain barrier function

被引：140

作者：

De Bock, Marijke ^{[1
]}

Wang, Nan ^{[1
]}

Decrock, Elke ^{[1
]}

Bol, Melissa ^{[1
]}

Gadicherla, Ashish K. ^{[1
]}

Culot, Maxime ^{[2
]}

Cecchelli, Romeo ^{[2
]}

Bultynck, Geert ^{[3
]}

Leybaert, Luc ^{[1
]}

机构：

[1] Univ Ghent, Dept Basic Med Sci, Physiol Grp, B-9000 Ghent, Belgium

[2] Univ Lille Nord France, Fac Jean Perrin, Lab Physiopathol Barriere Hematoencephal, F-62307 Lens, France

[3] Katholieke Univ Leuven, Lab Mol & Cellular Signaling, Dept Mol Cell Biol, B-3000 Louvain, Belgium

来源：

PROGRESS IN NEUROBIOLOGY | 2013年 / 108卷

关键词：

Blood-brain barrier; Endothelial permeability; Ca2+ dynamics; Connexin channels; PROTEIN-KINASE-C; LIGHT-CHAIN KINASE; CEREBRAL MICROVASCULAR PERMEABILITY; CELL-CULTURE MODEL; COLI K1 INVASION; JUNCTIONAL INTERCELLULAR COMMUNICATION; ARTERIOLAR SMOOTH-MUSCLE; TAT-INDUCED ALTERATIONS; IN-VITRO; TIGHT JUNCTIONS;

D O I：

10.1016/j.pneurobio.2013.06.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Situated between the circulation and the brain, the blood-brain barrier (BBB) protects the brain from circulating toxins while securing a specialized environment for neuro-glial signaling. BBB capillary endothelial cells exhibit low transcytotic activity and a tight, junctional network that, aided by the cytoskeleton, restricts paracellular permeability. The latter is subject of extensive research as it relates to neuropathology, edema and inflammation. A key determinant in regulating paracellular permeability is the endothelial cytoplasmic Ca2+ concentration ([Ca2+](i)) that affects junctional and cytoskeletal proteins. Ca2+ signals are not one-time events restricted to a single cell but often appear as oscillatory [Ca2+](i) changes that may propagate between cells as intercellular Ca2+ waves. The effect of Ca2+ oscillations/ waves on BBB function is largely unknown and we here review current evidence on how [Ca2+](i) dynamics influence BBB permeability. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1 / 20

页数：20

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