A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs

被引：39

作者：

Bagheri, H ^{[1
]}

Schmitt, L ^{[1
]}

Berlan, M ^{[1
]}

Montastruc, JL ^{[1
]}

机构：

[1] CHU PURPAN,SERV PSYCHIAT & PSYCHOL MED,F-31059 TOULOUSE,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1997年 / 52卷 / 05期

关键词：

yohimbine; salivary secretion; anetholtrithione; tricyclic antidepressants; alpha(2) adrenoceptor antagonists; dry mouth;

D O I：

10.1007/s002280050298

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: The present study compares the effects of yohimbine, an alpha(2) adrenoceptor antagonist, and anetholtrithione, a reference drug in the treatment of dry mouth, in patients treated with psychotropic drugs (tricyclic antidepressants or neuroleptics) and suffering from xerostomia. Methods: Ten patients were included in a randomized, double-blind, cross-over study, and receiving after yohimbine (3 x 6 mg per day) or anetholtrithione (3 x 25 mg per day) orally for 5 days. Salivary secretion was estimated under resting conditions, before any drug, and then on day 6, 1 h after the ingestion of yohimbine or anetholtrithione. Results: Compared with basal secretion, the increase in salivary flow was significantly more marked after yohimbine than after anetholtrithione. Conclusion: This study demonstrates the sialogenic effect of yohimbine in drug-induced dry mouth.

引用

页码：339 / 342

页数：4

共 21 条

[11]

HALPERN BN, 1950, ARCH INT PHARMACOD T, V83, P49

[12]

LELORD G, 1969, GAZ MED FR, V76, P2257

[13] THE ROLE OF SALIVA IN MAINTAINING ORAL HOMEOSTASIS [J].

MANDEL, ID .

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 1989, 119 (02) :298-304

[14] EFFECTS OF YOHIMBINE ON SUBMAXILLARY SALIVATION IN DOGS [J].

MONTASTRUC, P ;

BERLAN, M ;

MONTASTRUC, JL .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 98 (01) :101-104

[15] RELATIONSHIP BETWEEN SALIVARY FLOW-RATES AND CANDIDA-ALBICANS COUNTS [J].

NAVAZESH, M ;

WOOD, GJ ;

BRIGHTMAN, VJ .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1995, 80 (03) :284-288

[16]

PALMIERI B, 1980, RIV FARMACOL TER, V11, P299

[17] EFFECTS OF PILOCARPINE ON SALIVARY FLOW IN PATIENTS WITH SJOGRENS-SYNDROME [J].

RHODUS, NL ;

SCHUH, MJ .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1991, 72 (05) :545-549

[18]

SCHIODT M, 1986, SCAND J RHEUMATOL S, V61, P250

[19] XEROSTOMIA - A NEGLECTED SYMPTOM [J].

SREEBNY, LM ;

VALDINI, A .

ARCHIVES OF INTERNAL MEDICINE, 1987, 147 (07) :1333-1337

[20]

UKAI Y, 1984, ARCH INT PHARMACOD T, V271, P206

← 1 2 3 →