Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia

被引：12

作者：

Lan, Jing ^{[1
,2
]}

Esposito, Elga ^{[2
,3
]}

Ayata, Cenk ^{[3
]}

Singhal, Aneesh B. ^{[3
]}

Lo, Eng H. ^{[2
,3
]}

Ji, Xunming ^{[1
]}

机构：

[1] Capital Med Univ, China Amer Inst Neurosci, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

来源：

STROKE | 2018年 / 49卷 / 06期

基金：

国家重点研发计划; 美国国家卫生研究院; 中国国家自然科学基金;

关键词：

hypertension; middle cerebral artery; neuroprotection; reperfusion; transient ischemic attack; STROKE RESEARCH; HYPEROXIA; REPERFUSION; DAMAGE; EFFICACY; THERAPY; WINDOW;

D O I：

10.1161/STROKEAHA.118.020626

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose The efficacy of neuroprotective approaches in stroke may be influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia (NBO) in normotensive versus hypertensive rats subjected to transient focal cerebral ischemia. Methods Male Sprague-Dawley and spontaneously hypertensive rats were subjected to transient focal ischemia via intraluminal filament occlusions of the middle cerebral artery. NBO was started 15 minutes after ischemic onset and stopped at the time of reperfusion. Acute neurological deficits and tetrazolium-stained infarct volumes were quantified at 24 hours. Results NBO reduced mean infarct volumes by approximate to 50% (P=0.0064) in normotensive Sprague-Dawley rats subjected to 100 minutes transient ischemia. No effects of NBO were observed in hypertensive spontaneously hypertensive rats subjected to either 100 minutes or 75 minutes of transient ischemia. No significant changes in neurological outcomes were detectable in any group. Conclusions NBO reduced infarction in Sprague-Dawley but not in spontaneously hypertensive rats. These findings suggest that comorbidities may influence responses to potential treatments after stroke.

引用

页码：1534 / 1537

页数：4

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