Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia

被引：126

作者：

Kim, HY

Singhal, AB

Lo, EH

机构：

[1] Massachusetts Gen Hosp, Neuroprotect Res Lab, Dept Neurol, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Neuroprotect Res Lab, Dept Radiol, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

[4] Konkuk Univ, Sch Med, Dept Neurol, Seoul, South Korea

来源：

ANNALS OF NEUROLOGY | 2005年 / 57卷 / 04期

关键词：

D O I：

10.1002/ana.20430

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A major limitation in thrombolysis for acute ischemic stroke is the restricted time window for safe and effective therapy. Any method that can extend the reperfusion time window would be important. In this study, we show that normobaric hyperoxia extends the time window for effective reperfusion from 1 to 3 hours in rats subjected to focal cerebral ischemia. Normobaric hyperoxia did not increase cellular markers of superoxide generation or brain levels of matrix metalloproteinase-9. Normobaric hyperoxia may be a clinically feasible adjunct method for significantly increasing the time window for effective thrombolytic therapy in acute ischemic stroke.

引用

收藏

页码：571 / 575

页数：5

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