MicroRNA functions in animal development and human disease

被引：1099

作者：

Alvarez-Garcia, I

Miska, EA

机构：

[1] Univ Cambridge, Gurdon Inst, Wellcome Trust Canc Ctr Res UK, Cambridge CB2 1QN, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, England

来源：

DEVELOPMENT | 2005年 / 132卷 / 21期

关键词：

D O I：

10.1242/dev.02073

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Five years into the 'small RNA revolution' it is hard not to share in the excitement about the rapidly unravelling biology of microRNAs. Since the discovery of the first microRNA gene, lin-4, in the nematode Caenorhabditis elegans, many more of these short regulatory RNA genes have been identified in flowering plants, worms, flies, fish, frogs and mammals. Currently, about 2% of the known human genes encode microRNAs. MicroRNAs are essential for development and this review will summarise our current knowledge of animal microRNA function. We will also discuss the emerging links of microRNA biology to stem cell research and human disease, in particular cancer.

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收藏

页码：4653 / 4662

页数：10

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