Intracortical inhibition and facilitation are abnormal in Huntington's disease: A paired magnetic stimulation study

被引：74

作者：

Abbruzzese, G

Buccolieri, A

Marchese, R

Trompetto, C

Mandich, P

Schieppati, M

机构：

[1] UNIV GENOA,INST BIOL & GENET,GENOA,ITALY

[2] UNIV GENOA,INST HUMAN PHYSIOL,GENOA,ITALY

来源：

NEUROSCIENCE LETTERS | 1997年 / 228卷 / 02期

关键词：

paired transcranial magnetic stimulation; cortico-cortical inhibition; motor cortex; Huntington's disease; choreic dyskinesias;

D O I：

10.1016/S0304-3940(97)00363-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transcranial magnetic stimulation with a conditioning-test paradigm was used to assess cortico-cortical interactions in the motor cortex of 11 patients with Huntington's disease (HD) as compared to normal controls (NC). In the HD patients, threshold and amplitude of motor potentials evoked in the opponens pollicis muscle at rest were not significantly different from NC. The cortico-cortical inhibition at interstimulus intervals of 2-5 ms was significantly reduced and the cortico-cortical facilitation at longer intervals (10-25 ms) was significantly enhanced. Changes of intracortical inhibition and facilitation were related to clinical rating of choreic dyskinesias. The data support the hypothesis of a functional impairment of the motor cortex-basal ganglia loop in HD patients. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：87 / 90

页数：4

共 22 条

[1]

BIRD ED, 1973, LANCET, V1, P1090

[2] Abnormalities of the balance between inhibition and excitation in the, motor cortex of patients with cortical myoclonus [J].