PRIMATE MODELS OF MOVEMENT-DISORDERS OF BASAL GANGLIA ORIGIN

被引：2989

作者：

DELONG, MR

机构：

[1] Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, Meyer 5-185

来源：

TRENDS IN NEUROSCIENCES | 1990年 / 13卷 / 07期

关键词：

D O I：

10.1016/0166-2236(90)90110-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Movement disorders associated with basal ganglia dysfunction comprise a spectrum of abnormalities that range from the hypokinetic disorders (of which Parkinson's disease is the best-known example) at one extreme to the hyperkinetic disorders (exemplified by Huntington's disease and hemiballismus) at the other. Both extremes of this movement disorder spectrum can be accounted for by postulating specific disturbances within the basal ganglia-thalamocortical 'motor' circuit. In this paper, Mahlon DeLong describes the changes in neuronal activity in the motor circuit in animal models of hypo- and hyperkinetic disorders. © 1990.

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页码：281 / 285

页数：5

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