Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

被引：32

作者：

Roland, PS

Rybak, L

Hannley, M

Matz, G

Stewart, MG

Manolidis, S

Friedman, R

Weber, P

Owens, F

机构：

[1] Univ Texas, SW Med Ctr, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA

[2] So Illinois Sch Med, Div Otolaryngol, Springfield, IL USA

[3] Amer Acad Otolaryngol Head & Neck Surg, Alexandria, VA USA

[4] Loyola Univ, Med Ctr, Chicago, IL 60611 USA

[5] Baylor Coll Med, Dept Otorhinolaryngol, Houston, TX USA

[6] House Ear Clin, Los Angeles, CA USA

[7] Cleveland Clin Fdn, Dept Otolaryngol & Commun Disorders, Cleveland, OH USA

[8] Private Practice, Dallas, TX USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2004年 / 130卷 / 03期

关键词：

D O I：

10.1016/j.otohns.2003.12.008

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of, ototopical drops in clinical situations involving humans. STUDY DESIGN. We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically, into the middle ear space, are ototoxic in experimental animals.

引用

页码：S57 / S78

页数：22

共 61 条

[21] Transtympanic versus sustained-release administration of gentamicin: Kinetics, morphology, and function [J].