EPR investigations of the iron domain in neuromelanin

被引：50

作者：

Aime, S ^{[1
]}

Bergamasco, B ^{[1
]}

Biglino, D ^{[1
]}

Digilio, G ^{[1
]}

Fasano, M ^{[1
]}

Giamello, E ^{[1
]}

Lopiano, L ^{[1
]}

机构：

[1] UNIV TURIN, DEPT NEUROSCI, I-10126 TURIN, ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1997年 / 1361卷 / 01期

关键词：

EPR; neuromelanin; iron binding; substantia nigra;

D O I：

10.1016/S0925-4439(97)00014-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions between iron and neuromelanin (NM) have been studied by means of EPR spectroscopy. The variable temperature EPR spectral features of a specimen of NM extracted from normal human midbrains clearly indicate that iron is present as polynuclear oxy-hydroxy ferric aggregates as well as isolated Fe(III) centres. Ferric oxy-hydroxy phases are typical of the iron storage proteins ferritin and hemosiderin, but the comparison of the variable temperature EPR spectra of ferritin and NM highlights significant differences between the two iron(III)oxy-hydroxy domains. Moreover, further investigations on melanin models synthesised in the presence of either ferritin or a ferric salt as iron sources suggest that the same pathway of formation and inclusion of the polynuclear iron oxide is operating in NM and in the model systems, whatever is the source of iron.

引用

页码：49 / 58

页数：10

共 51 条

[31] COMPLEX-I, IRON, AND FERRITIN IN PARKINSONS-DISEASE SUBSTANTIA-NIGRA [J].