In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa

被引：330

作者：

Sergeev, A. M. ^{[1
]}

Gelikonov, V. M. ^{[1
]}

Gelikonov, G. V. ^{[1
]}

Feldchtein, F. I. ^{[1
]}

Kuranov, R. V. ^{[1
]}

Gladkova, N. D. ^{[1
]}

Shakhova, N. M. ^{[2
]}

Snopova, L. B. ^{[2
]}

Shakhov, A. V. ^{[2
]}

Kuznetzova, I. A. ^{[3
]}

Denisenko, A. N. ^{[3
]}

Pochinko, V. V. ^{[3
]}

Chumakov, Yu. P. ^{[3
]}

Streltzova, O. S. ^{[3
]}

机构：

[1] Russian Acad Sci, Inst Appl Phys, Nizhnii Novgorod 603600, Russia

[2] Nizhny Novgorod Med Acad, Nizhnii Novgorod 603005, Russia

[3] Nizhny Novgorod Reg Hosp, Nizhnii Novgorod, Russia

来源：

OPTICS EXPRESS | 1997年 / 1卷 / 13期

关键词：

D O I：

10.1364/OE.1.000432

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

First results of endoscopic applications of optical coherence tomography for in vivo studies of human mucosa in respiratory, gastrointestinal, urinary and genital tracts are presented. A novel endoscopic OCT (EOCT) system has been created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, larynx, stomach, urinary bladder, uterine cervix and body as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancered tissue are distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy. (C) 1997 Optical Society of America

引用

页码：432 / 440

页数：9