脑源性神经营养因子研究进展

被引：18

作者：

吴莎

华清泉

杨琨

蔡雷

机构：

[1] 武汉大学人民医院耳鼻咽喉-头颈外科

来源：

中华临床医师杂志(电子版) | 2013年 / 7卷 / 09期

关键词：

脑源性神经营养因子; 特应性皮炎; 卵巢上皮癌; 受体; 神经元; 变态反应病; 神经组织; BDNF; TrkB;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

<正>脑源性神经营养因子(BDNF)是继神经生长因子之后第二个被发现的神经营养因子[1],是一类分子量为12.3kD的碱性蛋白质,由119个氨基酸残基构成,并含有3对二硫键,在体内以二聚体的形式存在,主要分布在中枢神经系统,其中以海马及皮层组织中含量最高,另外在外周组织如心脏、肺、肌肉中也检测到BDNF的存在。BDNF不但对多种类型神经元的发育、分化以及神经的生长和再生起着维持和促进作用,而且在神经元损

引用

收藏

页码：3988 / 3990

页数：3

相关论文

共 15 条

[1] TrkB及其配体BDNF在卵巢上皮癌中的表达及其临床意义 [J].

李明伟 ;

刘继红 .

中国妇产科临床杂志, 2012, 13 (02) :122-125

[2]

Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease[J] . AkiraYoshii,MarthaConstantine‐Paton.Devel Neurobio . 2010 (5)

[3] Is Serum Brain-Derived Neurotrophic Factor a Biomarker for Cognitive Enhancement in Schizophrenia? [J].

Vinogradov, Sophia ;

Fisher, Melissa ;

Holland, Christine ;

Shelly, Wendy ;

Wolkowitz, Owen ;

Mellon, Synthia H. .

BIOLOGICAL PSYCHIATRY, 2009, 66 (06) :549-553

[4] Relationship of serum brain-derived neurotrophic factor level with other markers of disease severity in patients with atopic dermatitis [J].

Namura, Kenji ;

Hasegawa, Goji ;

Egawa, Masato ;

Matsumoto, Tadasu ;

Kobayashi, Rina ;

Yano, Tadashi ;

Katoh, Norito ;

Kishimoto, Saburo ;

Ohta, Mitsuhiro ;

Obayashi, Hiroshi ;

Ose, Hiroyuki ;

Fukui, Michiaki ;

Nakamura, Naoto ;

Yoshikawa, Toshikazu .

CLINICAL IMMUNOLOGY, 2007, 122 (02) :181-186

[5] Role of amygdala MAPK activation on immobility behavior of forced swim rats [J].

Huang, Tung-Yi ;

Lin, Chih-Hung .

BEHAVIOURAL BRAIN RESEARCH, 2006, 173 (01) :104-111

[6] Alzheimer's disease [J].

Blennow, Kaj ;

de Leon, Mony J. ;

Zetterberg, Henrik .

LANCET, 2006, 368 (9533) :387-403

[7] Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects [J].

Raap, U ;

Goltz, C ;

Deneka, N ;

Bruder, M ;

Renz, H ;

Kapp, A ;

Wedi, B .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (06) :1268-1275

[8] Brain-derived neurotrophic factor selectively enhances allergen-specific IgE production [J].

Kimata, H .

NEUROPEPTIDES, 2005, 39 (04) :379-383

[9]

Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer[J] . Ximena Montano,Mustafa B.A Djamgoz.FEBS Letters . 2004 (1)

[10] Classification and epidemiology of tinnitus [J].

Heller, AJ .

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2003, 36 (02) :239-+