Relationship of serum brain-derived neurotrophic factor level with other markers of disease severity in patients with atopic dermatitis

被引：34

作者：

Namura, Kenji

Hasegawa, Goji ^{[1
]}

Egawa, Masato

Matsumoto, Tadasu

Kobayashi, Rina

Yano, Tadashi

Katoh, Norito

Kishimoto, Saburo

Ohta, Mitsuhiro

Obayashi, Hiroshi

Ose, Hiroyuki

Fukui, Michiaki

Nakamura, Naoto

Yoshikawa, Toshikazu

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamikyo Ku, Kyoto 6020841, Japan

[2] Meiji Univ Oriental Med, Dept Internal Med, Kyoto 6290392, Japan

[3] Meiji Univ Oriental Med, Dept Geriatr Acupuncture & Moxibust, Kyoto 6290392, Japan

[4] Meiji Univ Oriental Med, Dept Hlth Promoting Acupuncture & Moxibust, Kyoto 6290392, Japan

[5] Grad Sch Med Sci, Dept Dermatol, Kyoto 6020841, Japan

[6] Kobe Pharmaceut Univ, Dept Med Biochem, Kobe, Hyogo 6588558, Japan

[7] Inst Bioresponse Informat, Kyoto 6020845, Japan

来源：

CLINICAL IMMUNOLOGY | 2007年 / 122卷 / 02期

关键词：

brain-derived neurotrophic factor; atopic dermatitis; eosinophils; Th1/Th2; cells;

D O I：

10.1016/j.clim.2006.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elevated serum Levels of neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have been reported in allergic and autoimmune diseases. The aim of this study was to assess serum levels of BDNF in patients with atopic dermatitis (AD) and to investigate the relationship of the BDNF level with other markers of disease severity. Serum BDNF concentration was significantly higher in patients with AD (n = 62) compared to control subjects (n = 20) (P < 0.01). Stepwise multiple regression analysis showed a significant influence of the peripheral blood eosinophil counts (F=6.90) and the percentage of CD4(+)IL-4(+) (Th2) cells (F=6.61). Moreover, after remission of AD patients with conventionally treated AD patients (n = 14), serum levels of BDNF, eosinophil counts and percentage of Th2 cells were decreased significantly. These results suggest that serum BDNF may be a useful marker of disease activity in AD and that both eosinophils and Th2 cells are major cellular sources of serum BDNF. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：181 / 186

页数：6

共 42 条

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