砷化物所致细胞恶性转化的信号通路研究进展

被引：7

作者：

李远

刘起展

机构：

[1] 南京医科大学公共卫生学院现代毒理学教育部重点实验室

来源：

中华预防医学杂志 | 2011年 / 07期

关键词：

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

<正>众多研究证实,长期摄入砷化物可引起多种癌症,因此,砷化合物已被国际癌症协会确认为人类确定致癌物,但由于砷化物致癌的实验动物模型一直未能成功建立,从而导致其致癌机制研究长期滞后。虽已提出一些砷化物致癌作用的分子机制假说,如氧化应激、细胞增殖与凋亡异常、DNA

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