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Molecular mechanisms of arsenic carcinogenesis

被引：12
作者：
Chuanshu Huang
Qingdong Ke
Max Costa
Xianglin Shi
机构：
[1] Nelson Institute of Environmental Medicine,
[2] New York University School of Medicine,undefined
[3] Health Effects Laboratory Division,undefined
[4] National Institute for Occupational Safety and Health,undefined
来源：
Molecular and Cellular Biochemistry | 2004年 / 255卷
关键词：
arsenic; carcinogenesis; gene expressin; reactive oxygen species; genetic toxicity; signal transduction; kinase; methylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.
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页码：57 / 66
页数：9
相关论文
共 699 条
[1]  
Zhang P(1999)The use of arsenic trioxide (As J Biol Regul Homeost Agents 13 195-200
[2]  
Agis H(1999)O Ann Hematol 78 329-332
[3]  
Weltermann A(1997)) in the treatment of acute promyelocytic leukemia Blood 89 3354-3360
[4]  
Mitterbauer G(1998)Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia Am J Pathol 153 1775-1785
[5]  
Thalhammer R(2000)Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients J Environ Pathol Toxicol Oncol 19 281-286
[6]  
Edelhauser M(2000)Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors J Environ Pathol Toxicol Oncol 19 129-138
[7]  
Seewann HL(2000)Mechanisms of arsenic carcinogenicity: Genetic or epigenetic mechanisms? Environ Health Perspect 108 655-661
[8]  
Valent P(2000)Predisposing factors in occupational lung cancer: Inorganic minerals and chromium Cancer Invest 18 174-182
[9]  
Lechner K(1989)Risk of internal cancers from arsenic in drinking water Biol Trace Elem Res 21 421-429
[10]  
Fonatsch C(1996)Arsenic in drinking water and bladder cancer Cancer Lett 98 227-231
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