鼻咽癌四野面颈联合野适形放疗可行性研究及近期疗效分析

被引：2

作者：

王方正

傅真富

王磊

朴永峰

机构：

[1] 浙江省肿瘤医院放疗科

来源：

实用肿瘤杂志 | 2012年 / 27卷 / 02期

关键词：

鼻咽肿瘤/放射疗法; 放射疗法,适形; 化学疗法,辅助; 缓解,自行; 随访研究; 可行性研究; 治疗结果;

D O I：

10.13267/j.cnki.syzlzz.2012.02.018

中图分类号：

R739.63 [咽肿瘤];

学科分类号：

100214 ;

摘要：

目的本研究采用四野面颈联合野放疗治疗鼻咽癌患者,分析急性放射性反应和近期疗效。方法101例初治鼻咽癌患者进行四野面颈联合野适形放疗,其中90例接受FP方案同步化疗及辅助性化疗。结果患者在7周内完成治疗计划,四野面颈联合野适形放疗获得了满意的剂量分布。鼻咽癌病灶完全缓解(completeremission,CR)为95.0%(96/101),部分缓解(partial remission,PR)5.0%(5/101),总有效率达100.0%,淋巴结病灶CR 90.1%(91/101),PR 6.9%(7/101),总有效率为97.0%,1年总生存率、无瘤生存率分别为100.0%、97.0%,不良反应主要为Ⅰ～Ⅱ级放射性黏膜炎、白细胞下降。结论四野面颈联合野适形放疗剂量分布满意,近期疗效满意,急性放射反应可耐受,远期疗效及组织损伤尚有待长期随访观察。

引用

页码：165 / 170

页数：6

共 13 条

[1] 鼻咽癌放疗后放射性脑病307例临床特征分析 [J].

王方正 ;

朴永峰 ;

王磊 ;

付真富 .

中华肿瘤防治杂志, 2011, 18 (04) :303-305

[2] 鼻咽癌后程加速超分割并缩野加量放射治疗的前瞻性研究 [J].

梁平 ;

蒙富斌 ;

王洪乾 ;

李济培 ;

何晓洪 .

实用肿瘤杂志, 2009, 24 (03) :274-276

[3] Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients [J].

Hsin, Chung-Han ;

Chen, Tsai-Hsin ;

Young, Yi-Ho ;

Liu, Wen-Shan .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2010, 143 (05) :662-668

[4]

Nasopharyngeal Carcinoma Treated With Reduced-Volume Intensity-Modulated Radiation Therapy: Report on the 3-Year Outcome of a Prospective Series[J] . Shaojun Lin,Jianji Pan,Lu Han,Xiuchun Zhang,Xiyi Liao,Jiade J. Lu.International Journal of Radiation Oncology, Biology, Physics . 2009 (4)

[5]

Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials[J] . Daniel T.T. Chua,Jun Ma,Jonathan S.T. Sham,Hai-Qiang Mai,Damon T.K. Choy,Ming-Huang Hong,Tai-Xiang Lu,Gordon K.H. Au,Hua-Qing Min.International Journal of Radiation Oncology, Biology, Physics . 2006 (5)

[6] Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ-C30 and H&N-35 modules [J].

Cengiz, M ;

Özyar, E ;

Esassolak, M ;

Altun, M ;

Akmansu, M ;

Sen, M ;

Uzel, Ö ;

Yavuz, A ;

Dalmaz, G ;

Uzal, C ;

Hiçsönmez, A ;

Sarihan, S ;

Kaplan, B ;

Atasoy, BM ;

Ulutin, C ;

Abacioglu, U ;

Demiral, AN ;

Hayran, M .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 63 (05) :1347-1353

[7]

Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience[J] . Anne W.M. Lee,W.M. Sze,Joseph S.K. Au,S.F. Leung,T.W. Leung,Daniel T.T. Chua,Benny C.Y. Zee,Stephen C.K. Law,Peter M.L. Teo,Stewart Y. Tung,Dora L.W. Kwong,W.H. Lau.International Journal of Radiation Oncology, Biology, Physics . 2005 (4)

[8]

Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: The Hong Kong experience[J] . Michael K.M. Kam,Peter M.L. Teo,Ricky M.C. Chau,K.Y. Cheung,Peter H.K. Choi,W.H. Kwan,S.F. Leung,Benny Zee,Anthony T.C. Chan.International Journal of Radiation Oncology, Biology, Physics . 2004 (5)

[9]

Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation[J] . Michael K.M Kam,Ricky M.C Chau,Joyce Suen,Peter H.K Choi,Peter M.L Teo.International Journal of Radiation Oncology, Biology, Physics . 2003 (1)

[10] Nasopharyngeal carcinoma. [J].

Al-Sarraf M. ;

Reddy M.S. .

Current Treatment Options in Oncology, 2002, 3 (1) :21-32

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