MMPs,TIMPs与缺血后血管源性脑水肿

被引:8
作者
全冠民
机构
[1] 天津医科大学总医院放射科天津
关键词
脑缺血; 血脑屏障; 血管源性脑水肿; MMP-9; TIMP-1;
D O I
暂无
中图分类号
R741.02 [神经病理学、病因学];
学科分类号
0710 ; 071006 ;
摘要
血管源性脑水肿 (VBE)是脑缺血病例急性期死亡的主要原因 ,研究其分子生物学机制对有效地预防与治疗VBE具有重要意义。基质金属蛋白酶 (MMP ,主要是MMP 9)与脑缺血后ECM降解和血脑屏障 (BBB)通透性增加密切相关。正常时MMPs内源性抑制剂 (TIMPs)与MMPs保持相对平衡。脑缺血后早期应用MMP抑制剂可阻断或减轻VBE。
引用
收藏
页码:281 / 283
页数:3
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