手性药物经皮吸收与代谢的立体选择性及其影响因素

被引：1

作者：

叶金翠 ^{[1
,2
]}

陈国神 ^{[2
]}

曾苏 ^{[1
]}

机构：

[1] 浙江大学药学院

[2] 浙江省医学科学院药物研究所

来源：

中国药学杂志 | 2009年 / 44卷 / 01期

关键词：

手性药物; 皮肤渗透; 立体选择性;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的综述手性药物经皮吸收与代谢的立体选择性及其影响因素。方法分析评述近年来国内、外相关文献资料。结果皮肤的组成潜在地提供了一个手性环境,手性药物对映体与皮肤手性物质的选择性结合会引起对映体间渗透性的不同。除皮肤手性环境外,其他一些因素如对映体与消旋体熔点的差异、手性促进剂的构象、手性辅料的对映体选择性吸附、前体药物的对映体选择性皮肤代谢等均可能引起对映体选择性皮肤渗透。结论手性药物皮肤吸收与代谢的对映体选择性及其影响因素研究可为其经皮给药制剂的研制及其前体药物的设计提供理论与技术支持。

引用

页码：6 / 10

页数：5

共 49 条

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