他汀类药物的临床应用及不良反应研究进展

被引：47

作者：

张冰

王莉莉

机构：

[1] 军事医学科学院毒物药物研究所

来源：

国际药学研究杂志 | 2013年 / 40卷 / 05期

关键词：

他汀类; 临床应用; 不良反应; 肝毒性; 肌毒性;

D O I：

10.13220/j.cnki.jipr.2013.05.016

中图分类号：

R972.6 [];

学科分类号：

1007 ;

摘要：

他汀类药物是一线降脂药物,也是心血管疾病的预防药物,临床应用和研究范围正不断扩大。他汀类药物临床应用研究主要关注心血管疾病一级预防、充血性心力衰竭的治疗、对糖尿病发病的影响等。近年来,他汀类药物的不良反应,特别是肝毒性和肌毒性也愈发引起人们的关注。肝毒性主要表现为转氨酶升高,严重者引起肝功能衰竭;肌毒性主要表现为肌痛、抽搐等,严重者会引起横纹肌溶解症。临床上主要采用监测血清丙氨酸转氨酶或磷酸肌酸激酶,结合临床表现并及时减量或停药的方法来防止严重不良反应的发生,一些新的治疗方案还在研究中。深入研究他汀类药物不良反应的发生机制,开发有效的辅助治疗方法或复方药物有助于该类药物的安全应用。

引用

页码：560 / 564+572 +572

页数：6

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