他汀类药物的临床应用及不良反应研究进展

被引：47

作者：

张冰

王莉莉

机构：

[1] 军事医学科学院毒物药物研究所

来源：

国际药学研究杂志 | 2013年 / 40卷 / 05期

关键词：

他汀类; 临床应用; 不良反应; 肝毒性; 肌毒性;

D O I：

10.13220/j.cnki.jipr.2013.05.016

中图分类号：

R972.6 [];

学科分类号：

1007 ;

摘要：

他汀类药物是一线降脂药物,也是心血管疾病的预防药物,临床应用和研究范围正不断扩大。他汀类药物临床应用研究主要关注心血管疾病一级预防、充血性心力衰竭的治疗、对糖尿病发病的影响等。近年来,他汀类药物的不良反应,特别是肝毒性和肌毒性也愈发引起人们的关注。肝毒性主要表现为转氨酶升高,严重者引起肝功能衰竭;肌毒性主要表现为肌痛、抽搐等,严重者会引起横纹肌溶解症。临床上主要采用监测血清丙氨酸转氨酶或磷酸肌酸激酶,结合临床表现并及时减量或停药的方法来防止严重不良反应的发生,一些新的治疗方案还在研究中。深入研究他汀类药物不良反应的发生机制,开发有效的辅助治疗方法或复方药物有助于该类药物的安全应用。

引用

页码：560 / 564+572 +572

页数：6

共 41 条

[1]

Liver toxicity of rosuvastatin therapy[J]. Giuseppe Famularo,Luca Miele,Giovanni Minisola,Antonio Grieco.World Journal of Gastroenterology. 2007(08)

[2]

Statins for primary prevention of cardiovascular disease: the benefits outweigh the risks[J] . C. Michael Minder,Roger S. Blumenthal,Michael J. Blaha.Current Opinion in Cardiology . 2013 (5)

[3]

Long-term Clinical Outcomes of Statin Use for Chronic Heart Failure: A Meta-analysis of 15 Prospective Studies[J] . Jian-Qiang Wang,Guo-Rong Wu,Zheng Wang,Xiao-Ping Dai,Xiang-Rong Li.Heart, Lung and Circulation . 2013

[4]

Protective effects of l -carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin[J] . Rute A.P. Costa,Mariana P. Fernandes,Nadja C. de Souza-Pinto,Aníbal E. Vercesi.European Journal of Pharmacology . 2013 (1-3)

[5] Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents [J].

Mallinson, Joanne E. ;

Constantin-Teodosiu, Dumitru ;

Glaves, Philip D. ;

Martin, Elizabeth A. ;

Davies, Wendy J. ;

Westwood, F. Russell ;

Sidaway, James E. ;

Greenhaff, Paul L. .

JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (24) :6389-6402

[6]

Nitric oxide prevents atorvastatin‐induced skeletal muscle dysfunction and alterations in mice[J] . Giuseppe D’Antona,Anna Mascaro,Angela Monopoli,Daniela Miglietta,Ennio Ongini,Roberto Bottinelli.Muscle Nerve . 2012 (1)

[7]

Statins are diabetogenic – Myth or reality?[J] . Naveed Sattar,Marja-Riitta Taskinen.Atherosclerosis (Supplements) (Component) . 2012 (1)

[8] Statin induced myotoxicity [J].

Sathasivam, Sivakumar .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2012, 23 (04) :317-324

[9] Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins [J].

Sirvent, P. ;

Fabre, O. ;

Bordenave, S. ;

Hillaire-Buys, D. ;

De Mauverger, E. Raynaud ;

Lacampagne, A. ;

Mercier, J. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 259 (02) :263-268

[10]

Statins in Heart Failure: The Paradox Between Large Randomized Clinical Trials and Real Life[J] . Paloma Gastelurrutia,Josep Lupón,Marta de Antonio,Agustin Urrutia,Crisanto Díez,Ramón Coll,Salvador Altimir,Antoni Bayes-Genis.Mayo Clinic Proceedings . 2012 (6)

← 1 2 3 4 5 →