溶栓治疗超急性脑梗塞的科学性和客观性

被引:4
作者
钟士江
李平
机构
[1] 武警医学院附属医院脑系科中心
关键词
超急性脑梗塞; 溶栓; 弥散加权成像; 灌注加权成像; 磁共振成像;
D O I
10.16548/j.2095-3720.2006.06.046
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
<正>循证医学在证实溶栓治疗脑梗塞有效的同时,也发现其导致出血尤其致死性颅内出血的危险也在增加。在利益和风险并存的情况下,建立一个临床可行的、客观的影像学标准,严格选择每一个适合溶栓治疗的患者,使溶栓治疗方法更加科学,显得尤为重要。溶栓治疗的靶目标是梗塞区的缺血性半暗带(Ischemic Penumbra, IP),IP的有无应是决定是否溶栓的根本依据,而目前研究者及临床医
引用
收藏
页码:611 / 613
页数:3
相关论文
共 13 条
[1]  
Monitoring intra- venous recombinant tissue plasminogen activator thrombolysis for a- cute ischemic stroke with diffusion and perfusion MRI. Schellinger PD,Jansen O,Fiebach JB,et al. Stroke . 2000
[2]  
Anonymous.Tissue plasminogen activator for acute ischemic stroke. The New England Journal of Medicine . 1995
[3]  
Characterizing the target of acute stroke therapy. Fisher M. Stroke . 1997
[4]  
Perfusion magnetic resonance imaging maps in hyperacute stroke:relative cerebral blood flow most accurately identifies tissue destined to infarct. Parsons MW,Yang Q,Barber PA,et al. Stroke . 2001
[5]  
Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. Hacke W,Kaste M,Fieschi C,et al. The Journal of The American Medical Association . 1995
[6]  
Hyperacute stroke:evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging. Sorensen AG,Buonanno FS,Gonzalez RG,et al. Radiology . 1996
[7]  
Cortical evoked potential and extracellular K+and H+at critical levels of brain ischemia. Astrup J,Symon L,Branston NM,et al. Stroke . 1981
[8]  
Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion- weighted MRI and apparent diffusion coefficient. Rohl L,Ostergaard L,Simonsen CZ,et al. Stroke . 2001
[9]   Neurology [C]. 
The 5th International Congress of Pathophysiology
,2006
[10]  
Magnetic resonance imaging of acute stroke. Baird AE,Warach S. J Cereb-Blood Flow Metab . 1998