阿托伐他汀钙对急性脑梗死患者血浆S100B和高迁移率族蛋白1水平的影响

被引：15

作者：

杜文秀 ^{[1
]}

李艳艳 ^{[1
]}

史路遥 ^{[1
]}

端光鑫 ^{[1
]}

尤寿江 ^{[1
]}

张霞 ^{[1
]}

冯萍 ^{[2
]}

曹勇军 ^{[1
]}

刘春风 ^{[1
]}

机构：

[1] 苏州大学附属第二医院神经内科

[2] 苏州大学附属第二医院检验科

来源：

中华老年心脑血管病杂志 | 2016年 / 18卷 / 09期

关键词：

脑梗死; 动脉粥样硬化; 高迁移率族蛋白质类; 降血脂药;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的观察不同剂量他汀类药物治疗对动脉粥样硬化性脑梗死患者血浆S100B和高迁移率族蛋白B1(highmobility group protein B1,HMGB1)水平的影响。方法选择大动脉粥样硬化性脑梗死患者298例,根据服用阿托伐他汀钙剂量分为他汀高剂量(40mg/晚)组106例,他汀标准剂量(20mg/晚)组134例,他汀空白组58例,另选择健康体检者67例作为对照组。记录各组入院时、7d血浆S100B、HMGB1水平及美国国立卫生研究院卒中量表(NIHSS)评分。结果他汀高剂量组、他汀标准剂量组、他汀空白组入院时S100B水平较对照组明显升高[(38.19±30.10)pg/L,(38.41±23.75)pg/L,(32.47±25.04)pg/L vs(24.57±12.15)pg/L,P<0.05,P<0.01]。与他汀空白组比较,他汀高剂量组、他汀标准剂量组7d时S100B水平明显降低(P<0.05)。与他汀标准剂量组比较,他汀高剂量组7d时S100B水平明显降低(P<0.05)。与入院时比较,他汀空白组7d时S100B水平明显升高,他汀高剂量组7d时S100B水平明显降低(P<0.05,P<0.01)。入院时S100B水平与HDL-C(r=-0.224,P=0.010)、脑梗死体积(r=0.272,P=0.004)相关。结论阿托伐他汀钙不仅能调节血脂水平,还能降低炎性因子S100B水平,可能是其发挥抗炎及神经保护功能的机制之一。

引用

页码：938 / 942

页数：5

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