脑缺血后TLR4作用与小胶质细胞的激活

被引：1

作者：

张瑜

金芬华

任志鹏

李芃

车永哲

机构：

[1] 南开大学医学院

来源：

国际病理科学与临床杂志 | 2008年 / 04期

关键词：

TLR4; 脑缺血; 小胶质细胞; 信号转导通路;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

脑缺血性损伤早期小胶质细胞即被激活。激活的小胶质细胞既有细胞毒性又有神经营养作用。小胶质细胞行使免疫功能的信号转导受体之一是TLR4(toll-like receptor 4)。TLR4在脑内主要表达在小胶质细胞,是一种模式识别受体(pattern recognition receptor,PRR),识别一些外源性和内源性的配体。最近的研究表明,TLR4信号通路在脑缺血再灌注损伤中起重要作用。TLR4通过激活小胶质细胞,大量表达炎症因子,加重脑缺血性损伤。

引用

页码：334 / 338

页数：5

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