TLR signaling

被引：1402

作者：

Kawai, Taro

Akira, Shizuo

机构：

[1] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

[2] Osaka Univ, ERATO, Japan Sci & Technol Agcy, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 01期

关键词：

innate immunity; signal transduction; Toll-like receptor;

D O I：

10.1016/j.smim.2006.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The TLR family senses the molecular signatures of microbial pathogens, and plays a fundamental role in innate immune responses. TLRs signal via a common pathway that leads to the expression of diverse inflammatory genes. In addition, each TLR elicits specific cellular responses to pathogens owing to differential usage of intracellular adapter proteins. Recent studies have revealed the importance of the subcellular localization of TLRs in pathogen recognition and signaling. TLR signaling pathways is negatively regulated by a number of cellular proteins to attenuate inflammation. Here, we describe recent advances in our understanding of the regulation of TLR-mediated signaling. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：24 / 32

页数：9

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