蛋白质同型半胱氨酸化与动脉粥样硬化机制

被引：6

作者：

吴云飞

钟良玮

机构：

[1] 中国科学院研究生院生命科学学院

来源：

中国科学院研究生院学报 | 2009年 / 26卷 / 02期

关键词：

血管内皮细胞; 高同型半胱氨酸血症; 动脉粥样硬化; 氧化应激; 内质网应激;

D O I：

暂无

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

动脉粥样硬化是严重危害人类生命健康的世界性疾病,因发病机制至今未明,尚无有效防治措施.大量研究证明,高同型半胱氨酸血症是引起动脉粥样硬化的独立危险因素.高同型半胱氨酸血症与氧化应激、内质网应激、血管内皮细胞损伤及血液粘稠度增高之间的密切关系已有大量文献报道,但其具体机制有待阐明.综述简要介绍了近年来在国际上颇受关注的蛋白质同型半胱氨酸化.围绕抗氧化酶、内质网蛋白、凝血因子、低密度脂蛋白,以及与钙信号有关的蛋白被同型半胱氨酸化的研究发现,从同型半胱氨酸及其衍生物同型半胱氨酸巯基内酯对蛋白质的共价修饰反应,到使分子结构与理化性质发生改变的生化机制,阐述了这种修饰与动脉粥样硬化斑块形成的关系.

引用

页码：145 / 151

页数：7

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