内质网应激与膜性肾病

被引：8

作者：

李静

夏正坤

机构：

[1] 南京大学医学院临床学院(南京军区南京总医院)儿科

来源：

医学研究生学报 | 2011年 / 05期

关键词：

内质网应激; 未折叠蛋白反应; 膜性肾病; 钙离子;

D O I：

暂无

中图分类号：

R692.9 [其他疾病];

学科分类号：

1002 ; 100210 ;

摘要：

内质网(endoplasmic reticulum,ER)是调节蛋白质合成、折叠及组装的重要场所。各种原因如ER中Ca2+缺乏均可引起ER功能紊乱,使蛋白质从ER向高尔基体的转运受阻[1],最终引发内质网应激(endoplasmic reticulum stress,ERS)。细胞通过激活未折叠蛋白反应(the unfolded protein response,UPR)保护ERS引起损伤的细胞,强烈或持久的ERS又可启动UPR的促凋亡信号。肾病尤其是膜性肾病(membranous nephropathy,MN)的发生发展与ERS密切相关,文中主要阐述ERS在MN发病机制中的作用。

引用

页码：542 / 546

页数：5

共 12 条

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