PI3K/AKT/GSK-3β信号通路与心肌缺血/再灌注损伤的相关性研究附视频

被引：18

作者：

杨述亮 ^{[1
]}

韩燕 ^{[1
]}

李占清 ^{[2
]}

机构：

[1] 河北联合大学研究生学院

[2] 河北联合大学附属医院胸心外科

来源：

医学综述 | 2015年 / 09期

关键词：

心肌缺血/再灌注损伤; 磷脂酰肌醇-3-激酶; 蛋白激酶B; 糖原合成酶激酶3β; 信号通路;

D O I：

暂无

中图分类号：

R542.2 [心肌疾病];

学科分类号：

1002 ; 100201 ;

摘要：

磷脂酰肌醇-3-激酶/蛋白激酶B(PI3K/AKT)信号通路在肿瘤细胞中被发现。随着分子医学的发展,研究发现,该通路通过调控下游的多种效应分子对器官的缺血/再灌注损伤起保护作用,其中糖原合成酶激酶3β(GSK-3β)是主要效应分子,两者联合被称为PI3K/AKT/GSK-3β信号通路。该通路在心肌细胞缺血/缺氧培养、心肌暖缺血/再灌注损伤及离体心脏心肌缺血/再灌注损伤中的保护作用已经得到证实,但在心脏移植中对于心肌缺血冷保护及移植后的再灌注损伤的作用报道较少,需要进一步探讨。

引用

页码：1571 / 1574

页数：4

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