ON THE RATIONAL DESIGN OF RENIN INHIBITORS - X-RAY STUDIES OF ASPARTIC PROTEINASES COMPLEXED WITH TRANSITION-STATE ANALOGS

被引：112

作者：

BLUNDELL, TL ^{[1
]}

COOPER, J ^{[1
]}

FOUNDLING, SI ^{[1
]}

JONES, DM ^{[1
]}

ATRASH, B ^{[1
]}

SZELKE, M ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT CHEM PATHOL,LONDON W12 0HS,ENGLAND

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 18期

关键词：

D O I：

10.1021/bi00392a001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：5585 / 5590

页数：6

共 52 条

[21]

HARTSUCK JA, 1972, J BIOL CHEM, V247, P2575

[22] ENERGY CALCULATIONS ON ASPARTIC PROTEINASES - HUMAN RENIN, ENDOTHIAPEPSIN AND ITS COMPLEX WITH AN ANGIOTENSINOGEN FRAGMENT ANALOG, H-142 [J].

HEMMINGS, AM ;

FOUNDLING, SI ;

SIBANDA, BL ;

WOOD, SP ;

PEARL, LH ;

BLUNDELL, T .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1985, 13 (06) :1036-1041

[23] INHIBITION OF RENIN - RECENT IMMUNOLOGICAL AND PHARMACOLOGICAL ADVANCES [J].

HOFBAUER, KG ;

WOOD, JM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1985, 6 (04) :173-177

[24] CRYOENZYMOLOGY OF PENICILLOPEPSIN - APPENDIX - MECHANISM OF ACTION OF ASPARTYL PROTEINASES [J].

HOFMANN, T ;

DUNN, BM ;

FINK, AL .

BIOCHEMISTRY, 1984, 23 (22) :5247-5256

[25] MOLECULAR-STRUCTURE OF AN ASPARTIC PROTEINASE ZYMOGEN, PORCINE PEPSINOGEN, AT 1.8 A RESOLUTION [J].

JAMES, MNG ;

SIELECKI, AR .

NATURE, 1986, 319 (6048) :33-38

[26] CONFORMATIONAL FLEXIBILITY IN THE ACTIVE-SITES OF ASPARTYL PROTEINASES REVEALED BY A PEPSTATIN FRAGMENT BINDING TO PENICILLOPEPSIN [J].

JAMES, MNG ;

SIELECKI, A ;

SALITURO, F ;

RICH, DH ;

HOFMANN, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (20) :6137-6141

[27] STRUCTURE AND REFINEMENT OF PENICILLOPEPSIN AT 1.8-A RESOLUTION [J].

JAMES, MNG ;

SIELECKI, AR .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 163 (02) :299-361

[28] STEREOCHEMICAL ANALYSIS OF PEPTIDE-BOND HYDROLYSIS CATALYZED BY THE ASPARTIC PROTEINASE PENICILLOPEPSIN [J].

JAMES, MNG ;

SIELECKI, AR .

BIOCHEMISTRY, 1985, 24 (14) :3701-3713

[29]

JONES M, 1985, 9TH P AM PEPT S, P759

[30]

KOKUBU T, 1973, BIOCHEM PHARMACOL, V22, P3217

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