ENHANCEMENT OF THE ORAL ABSORPTION OF CYCLOSPORINE IN MAN

被引：69

作者：

DREWE, J

MEIER, R

VONDERSCHER, J

KISS, D

POSANSKI, U

KISSEL, T

GYR, K

机构：

[1] KANTONSSPITAL LIESTAL, DEPT INTERNAL MED, CH-4410 LIESTAL, SWITZERLAND

[2] SANDOZ PHARMA LTD, PHARMA DEV, CH-4002 BASEL, SWITZERLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 34卷 / 01期

关键词：

CYCLOSPORINE; ORAL ABSORPTION; MICROEMULSION;

D O I：

10.1111/j.1365-2125.1992.tb04108.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The oral absorption of cyclosporin from three new semi-solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2 The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.

引用

收藏

页码：60 / 64

页数：5

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