SIALOADHESIN, A MACROPHAGE SIALIC-ACID BINDING-RECEPTOR FOR HEMATOPOIETIC-CELLS WITH 17 IMMUNOGLOBULIN-LIKE DOMAINS

被引:228
作者
CROCKER, PR
MUCKLOW, S
BOUCKSON, V
MCWILLIAM, A
WILLIS, AC
GORDON, S
MILON, G
KELM, S
BRADFIELD, P
机构
[1] UNIV OXFORD, SIR WILLIAM DUNN SCH PATHOL, OXFORD OX1 3RE, ENGLAND
[2] INST PASTEUR, F-75724 PARIS 15, FRANCE
[3] UNIV OXFORD, DEPT BIOCHEM, MRC, IMMUNOCHEM UNIT, OXFORD OX1 3RE, ENGLAND
[4] CHRISTIAN ALBRECHTS UNIV KIEL, INST BIOCHEM 2, D-24098 KIEL, GERMANY
基金
英国惠康基金;
关键词
ADHESION; BONE MARROW; IMMUNOGLOBULIN; MACROPHAGE; SIALIC ACID; SIALOADHESIN;
D O I
10.1002/j.1460-2075.1994.tb06771.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sialoadhesin is a macrophage-restricted adhesion molecule of 185 kDa that mediates sialic acid-dependent binding to cells. It is expressed strongly by macrophages in lymphoid and haemopoietic tissues where it is likely to mediate cell-cell interactions. Here we report the molecular cloning of murine sialoadhesin and show that it is a new member of the immunoglobulin (Ig) superfamily with 17 Ig-like domains. COS cells transfected with a cDNA encoding full-length sialoadhesin bound mouse bone marrow cells in a sialic acid-dependent manner. Alternatively spliced cDNAs, predicting soluble forms of sialoadhesin containing the first three or 16 Ig-like domains of sialoadhesin, were expressed in COS cells and the respective proteins purified. When immobilized on plastic, the 16-domain form bound cells in a sialic acid-dependent manner, suggesting that sialoadhesin can function in both secreted and membrane-bound forms. The most similar proteins in the database were CD22, myelin-associated glycoprotein, Schwann cell myelin protein and CD33. Like sialoadhesin, CD22 mediates sialic acid-dependent cell adhesion. The sequence similarity of sialoadhesin to CD22 and related members of the Ig superfamily indicates the existence of a novel family of sialic acid binding proteins involved in cell-cell interactions.
引用
收藏
页码:4490 / 4503
页数:14
相关论文
共 71 条
[41]  
NORGARD KE, 1993, J BIOL CHEM, V268, P12764
[42]  
OIKAWA S, 1991, J BIOL CHEM, V266, P7995
[43]   ASSOCIATION OF CD22 WITH THE B-CELL ANTIGEN RECEPTOR [J].
PEAKER, CJG ;
NEUBERGER, MS .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (06) :1358-1363
[44]   THE MYELIN-ASSOCIATED GLYCOPROTEINS - MEMBRANE DISPOSITION, EVIDENCE OF A NOVEL DISULFIDE LINKAGE BETWEEN IMMUNOGLOBULIN-LIKE DOMAINS, AND POSTTRANSLATIONAL PALMITYLATION [J].
PEDRAZA, L ;
OWENS, GC ;
GREEN, LAD ;
SALZER, JL .
JOURNAL OF CELL BIOLOGY, 1990, 111 (06) :2651-2661
[45]  
PEIPER SC, 1988, BLOOD, V72, P314
[46]  
PEIPER SC, 1989, LEUCOCYTE TYPING, V4, P814
[47]   THE REGULATED PRODUCTION OF MU-M AND MU-S MESSENGER-RNA IS DEPENDENT ON THE RELATIVE EFFICIENCIES OF MU-S POLY(A) SITE USAGE AND THE C-MU-4-TO-M1 SPLICE [J].
PETERSON, ML ;
PERRY, RP .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) :726-738
[48]  
PETERSON ML, 1994, HDB B T LYMPHOCYTES, P321
[49]   MYELIN-ASSOCIATED GLYCOPROTEIN, A MEMBER OF THE L2/HNK-1 FAMILY OF NEURAL CELL-ADHESION MOLECULES, IS INVOLVED IN NEURON OLIGODENDROCYTE AND OLIGODENDROCYTE OLIGODENDROCYTE INTERACTION [J].
POLTORAK, M ;
SADOUL, R ;
KEILHAUER, G ;
LANDA, C ;
FAHRIG, T ;
SCHACHNER, M .
JOURNAL OF CELL BIOLOGY, 1987, 105 (04) :1893-1899
[50]  
POWELL LD, 1993, J BIOL CHEM, V268, P7019