PEPTIDE SEQUENCES THAT TARGET CYTOSOLIC PROTEINS FOR LYSOSOMAL PROTEOLYSIS

被引：557

作者：

DICE, JF ^{[1
]}

机构：

[1] TUFTS UNIV,SCH VET MED,BOSTON,MA 02111

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 08期

关键词：

D O I：

10.1016/0968-0004(90)90019-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysosomes take up and degrade intracellular proteins in cultured cells in response to serum deprivation, and in tissues of organisms in response to starvation. One mechanism by which proteins enter lysosomes for subsequent degradation requires that substrate proteins contain peptide sequences biochemically related to Lys-Phe-Glu-Arg-Gln (KFERQ). © 1990.

引用

页码：305 / 309

页数：5

共 29 条

[21]

LUSCHER B, 1988, MOL CELL BIOL, V8, P2504

[22]

MAJERUS PW, 1969, J BIOL CHEM, V244, P6254

[23]

MCELLIGOTT MA, 1985, J BIOL CHEM, V260, P1986

[24] QUANTITATIVE CORRELATION BETWEEN PROTEOLYSIS AND MACROAUTOPHAGY AND MICROAUTOPHAGY IN MOUSE HEPATOCYTES DURING STARVATION AND REFEEDING [J].