MANGANESE SUPEROXIDE-DISMUTASE - NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF A CDNA-ENCODING A NEW HUMAN TRANSCRIPT

被引：47

作者：

CHURCH, SL

机构：

[1] Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MI

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1087卷 / 02期

关键词：

(Human); Amino acid sequence; cDNA cloning; Gene expression; Manganese enzyme; Superoxide dismutase;

D O I：

10.1016/0167-4781(90)90213-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three human cDNA libraries were screened with a human manganese superoxide dismutase (Mn-SOD) cDNA under moderately stringent conditions to characterize a large 4-6 kb RNA species which hybridizes to Mn-SOD in RNA blot analyses. A new 4.2 kb Mn-SOD cDNA clone (Mn-SOD 1) was isolated. Its long 3426 nucleotide 3′-untranslated sequence contains both of the 240 base 3′-untranslated sequences of the 1 kb Mn-SOD 4 and 5 cDNAs. This is a fully processed, cytoplasmic RNA species and raises the possibility of a role for particular 3′-untranslated sequence selection in Mn-SOD gene regulation. © 1990.

引用

页码：250 / 252

页数：3

共 16 条

[11] REPETITIVE SEQUENCES IN EUKARYOTIC DNA AND THEIR EXPRESSION [J].

JELINEK, WR ;

SCHMID, CW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1982, 51 :813-844

[12] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].

SANGER, F ;

NICKLEN, S ;

COULSON, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467

[13] SPECULATIONS ON RNA SPLICING [J].

SHARP, PA .

CELL, 1981, 23 (03) :643-646

[14] A CONSERVED AU SEQUENCE FROM THE 3' UNTRANSLATED REGION OF GM-CSF MESSENGER-RNA MEDIATES SELECTIVE MESSENGER-RNA DEGRADATION [J].

SHAW, G ;

KAMEN, R .

CELL, 1986, 46 (05) :659-667

[15] SYNTHESIS AND PROCESSING OF THE PRECURSOR FOR HUMAN MANGANO-SUPEROXIDE DISMUTASE [J].

WISPE, JR ;

CLARK, JC ;

BURHANS, MS ;

KROPP, KE ;

KORFHAGEN, TR ;

WHITSETT, JA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 994 (01) :30-36

[16] MULTIPLE TAQ-I RFLPS AT THE HUMAN MANGANESE SUPEROXIDE-DISMUTASE (S0D2) LOCUS ON CHROMOSOME-6 [J].

XIANG, K ;

COX, NJ ;

HALLEWELL, RA ;

BELL, GI .

NUCLEIC ACIDS RESEARCH, 1987, 15 (18) :7654-7654

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