A LACK OF EFFECT OF CAPTOPRIL ON PLATELET-AGGREGATION IN PATIENTS WITH CONGESTIVE-HEART-FAILURE

被引：7

作者：

GOW, IF

FLAPAN, AD

MORRIS, M

DAVIES, E

WILLIAMS, BC

PADFIELD, PL

SHAW, TRD

EDWARDS, CRW

机构：

[1] WESTERN GEN HOSP, DEPT MED, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

[2] WESTERN GEN HOSP, DEPT CARDIOL, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 01期

关键词：

CAPTOPRIL; BLOOD PLATELETS; ANGIOTENSIN-II; 5-HYDROXYTRYPTAMINE; PLATELET AGGREGATION; ANGIOTENSIN-II; ESSENTIAL-HYPERTENSION; CONVERTING ENZYME; PLASMA; RADIOIMMUNOASSAY; PROSTACYCLIN; SEROTONIN; RELEASE; MEN;

D O I：

10.1007/BF00280105

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have studied the acute and chronic effects of an ACE inhibitor (captopril) on platelet function and the renin-angiotensin system in patients with congestive heart failure. Plasma concentrations of angiotensin II fell significantly after a single dose of captopril (25 mg) and during long-term treatment with captopril (2 weeks, 75 mg/day). Plasma renin activity increased significantly after both the single and repeated doses. Captopril did not affect ADP-induced platelet aggregation or concentrations. It seems unlikely that circulating angiotensin II affects ADP-induced platelet aggregation in patients with congestive heart failure.

引用

页码：47 / 49

页数：3

共 22 条

[1]

BORN GVR, 1985, ADV EXP MED BIOL, V192, P399

[2] PLATELET-RELEASE AND THROMBOXANE SYNTHESIS IN SYMPTOMATIC CORONARY-ARTERY DISEASE [J].