DOUBLE-BLIND PLACEBO CONTROLLED CROSSOVER STUDY OF PROSTACYCLIN IN MAN

被引：135

作者：

FITZGERALD, GA ^{[1
]}

FRIEDMAN, LA ^{[1
]}

MIYAMORI, I ^{[1
]}

OGRADY, J ^{[1
]}

LEWIS, PJ ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT CLIN PHARMACOL,LONDON EC1A 7BE,ENGLAND

来源：

LIFE SCIENCES | 1979年 / 25卷 / 08期

关键词：

D O I：

10.1016/0024-3205(79)90507-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Prostacyclin sodium (PGI2) was administered in a double blind crossover trial to 6 normal males at infusion rates of 2, 4 and 8 ng/kg/minute. Substantial (p < 0.001) shifts of the log dose response curve of ADP induced platelet aggregation occured during the highest infusion rate of PGI2. This was associated with a small but significant fall in diastolic blood pressure (-6.3± 1.6 mm Hg, p < 0.01) and a rise in heart rate (+25.5 ± 6.5 beats/minute, p < 0.001). Plasma renin activity rose in a dose related manner with PGI2 but plasma aldosterone and plasma norepinephrine did not change. Marked facial flushing occured with PGI2. © 1979.

引用

页码：665 / 672

页数：8

共 20 条

[1]

CAMPBELL WB, 1978, CIRCULATION, V58, P251

[2] GENERATION OF PROSTACYCLIN BY ARTERIES AND BY CORONARY VASCULAR BED IS REDUCED IN EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS [J].

DEMBINSKAKIEC, A ;

GRYGLEWSKA, T ;

ZMUDA, A ;

GRYGLEWSKI, RJ .

PROSTAGLANDINS, 1977, 14 (06) :1025-1034

[3] A COMPARISON OF THE EFFECTS OF PULSATILE AND NON-PULSATILE BLOOD FLOW THROUGH THE CAROTID SINUS ON THE REFLEXOGENIC ACTIVITY OF THE SINUS BAROCEPTORS IN THE CAT [J].

EAD, HW ;

GREEN, JH ;

NEIL, E .

JOURNAL OF PHYSIOLOGY-LONDON, 1952, 118 (04) :509-519

[4] MODULATION OF HUMAN PLATELET ADENYLATE-CYCLASE BY PROSTACYCLIN (PGX) [J].

GORMAN, RR ;

BUNTING, S ;

MILLER, OV .

PROSTAGLANDINS, 1977, 13 (03) :377-388

[5] RELEASE OF PROSTAGLANDINS MAY BE RESPONSIBLE FOR ACUTE TOLERANCE TO NOREPINEPHRINE INFUSIONS [J].

GRYGLEWSKI, RJ ;

OCETKIEWICZ, A .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1974, 8 (01) :31-42

[6] GENERATION OF PROSTACYCLIN BY LUNGS INVIVO AND ITS RELEASE INTO ARTERIAL CIRCULATION [J].

GRYGLEWSKI, RJ ;

KORBUT, R ;

OCETKIEWICZ, A .

NATURE, 1978, 273 (5665) :765-767

[7] SENSITIVE RADIOENZYMATIC ASSAY FOR NOREPINEPHRINE IN TISSUES AND PLASMA [J].

HENRY, DP ;

STARMAN, BJ ;

JOHNSON, DG ;

WILLIAMS, RH .

LIFE SCIENCES, 1975, 16 (03) :375-384

[8]

HINTZE TH, 1978, CIRCULATION, P67

[9]

LORD E, 1947, BIOMETRIKA, V34, P41, DOI 10.1093/biomet/34.1-2.41

[10]

MONCADA S, 1978, LANCET, V1, P1286

← 1 2 →