ACCELERATION OF INTRACELLULAR CALCIUM WAVES IN XENOPUS-OOCYTES BY CALCIUM INFLUX

被引：150

作者：

GIRARD, S ^{[1
]}

CLAPHAM, D ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN, DEPT PHARMACOL, ROCHESTER, MN 55905 USA

来源：

SCIENCE | 1993年 / 260卷 / 5105期

关键词：

D O I：

10.1126/science.8385801

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many cell membrane receptors stimulate the phosphoinositide (PI) cycle, which produces complex intracellular calcium signals that regulate diverse processes such as secretion and transcription. A major messenger of this cycle, inositol 1,4,5-trisphosphate (IP3), stimulates its receptor channel on the endoplasmic reticulum to release calcium into the cytosol. Activation of the PI cycle also induces calcium influx, which refills the intracellular calcium stores. Confocal microscopy was used to show that receptor-activated calcium influx, enhanced by hyperpolarization, modulates the frequency and velocity of IP3-dependent calcium waves in Xenopus laevis oocytes. These results demonstrate that transmembrane voltage and calcium influx pathways may regulate spatial and temporal patterns of IP3-dependent calcium release.

引用

页码：229 / 232

页数：4

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