TRANSCRIPTION FACTORS IN EARLY T-CELL DEVELOPMENT

被引：50

作者：

CLEVERS, HC ^{[1
]}

OOSTERWEGEL, MA ^{[1
]}

GEORGOPOULOS, K ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP E,SCH MED,CUTANEOUS BIOL RES CTR,BOSTON,MA 02114

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期

关键词：

D O I：

10.1016/0167-5699(93)90198-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Characterization of the transcription control regions for most genes encoding the TCR-CD3 complex has been followed by identification of DNA-binding factors, some of which are restricted to lymphoid or T-lineage cells. The sequential expression of these factors is linked with the appearance of stage-specific T-cell markers, thus controlling the commitment of the elusive lymphoid progenitor cell and its progression along the T-lineage. Here, Hans Clevers, Mariette Oosterwegel and Katia Georgopoulos discuss recent progress made in the recognition of transcription factors that regulate these early events in T-cell ontogeny.

引用

页码：591 / 596

页数：6

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