GABA(A) RECEPTOR BETA(1),BETA(2), AND BETA(3) SUBUNITS - COMPARISONS IN DBA/2J AND C57BL/6J MICE

被引：28

作者：

KAMATCHI, GL ^{[1
]}

KOFUJI, P ^{[1
]}

WANG, JB ^{[1
]}

FERNANDO, JCR ^{[1
]}

LIU, ZF ^{[1
]}

MATHURA, JR ^{[1
]}

BURT, DR ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1261卷 / 01期

关键词：

GABA BENZODIAZEPINE RECEPTOR; GAMMA-AMINOBUTYRIC ACID; EPILEPSY; ALCOHOL; CDNA; RFLP; GENE MAPPING; (MOUSE);

D O I：

10.1016/0167-4781(95)00009-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GABA(A) receptors link binding of GABA (gamma-aminobutyric acid) to inhibitory chloride flux in the brain. They are the site of action of several important classes of drugs, and have been implicated in animal models of epilepsy and in the actions of alcohol. We compare the sequence and expression of the beta 1, beta 2 and beta 3 subunits of GABA(A) receptors in two inbred strains of mice, DBA/21 and CK57BL/61, which differ markedly in seizure susceptibility and in a variety of behaviors related in alcohol. Only the beta 3 subunit had strain differences in cDNA nucleotide sequence, which did not affect amino acid sequence but which did create restriction fragment length polymorphisms (RFLPs) potentially useful in gene mapping. We have also tested mouse beta 1 and beta 2 subunits for internal alternative splicing, detecting none.

引用

页码：134 / 142

页数：9

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