GABA-A RECEPTOR SUBTYPES - FROM PHARMACOLOGY TO MOLECULAR-BIOLOGY

被引：461

作者：

BURT, DR

KAMATCHI, GL

机构：

[1] Department of Pharmacology, University of Maryland, School of Medicine, Baltimore

来源：

FASEB JOURNAL | 1991年 / 5卷 / 14期

关键词：

GAMMA-AMINOBUTYRIC ACID; GABA RECEPTORS; BENZODIAZEPINES; BARBITURATES; ALCOHOL;

D O I：

10.1096/fasebj.5.14.1661244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GABA(A) receptors are GABA (gamma-aminobutyric acid)-gated chloride channels, which are major mediators of neuronal inhibition in the brain and are modulated by benzodiazepines, barbiturates, alcohol, and other important centrally acting drugs. Although previous pharmacological and biochemical data had suggested a degree of heterogeneity, recent cloning of at least 15 different receptor subunits, thought to be combined in groups of five, indicates that the brain may contain a truly astonishing variety of GABA(A) receptor subtypes. This review describes the little that is known about these subtypes, emphasizing possible molecular bases of receptor heterogeneity. We also discuss approaches to establishing the subunit composition of subtypes.

引用

页码：2916 / 2923

页数：8

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