DEHYDROEPIANDROSTERONE - ANTIGLUCOCORTICOID ACTION IN MICE

被引：78

作者：

BROWNE, ES

WRIGHT, BE

PORTER, JR

SVEC, F

机构：

[1] LOUISIANA STATE UNIV,MED CTR,SCH MED,DEPT MED,ENDOCRINOL SECT,1542 TULANE AVE,NEW ORLEANS,LA 70112

[2] LOUISIANA STATE UNIV,MED CTR,SCH MED,DEPT PHYSIOL,OBES RES PROGRAM,NEW ORLEANS,LA 70112

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1992年 / 303卷 / 06期

关键词：

DHEA; DEXAMETHASONE; TYROSINE AMINOTRANSFERASE; ORNITHINE DECARBOXYLASE; LIVER; KIDNEY; MICE; GLUCOCORTICOID ANTAGONISTS; ANTIGLUCOCORTICOIDS;

D O I：

10.1097/00000441-199206000-00003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The acute effect of dehydroepiandrosterone (DHEA) and its conjugate, DHEA-sulfate (DHEA-S) on glucocorticoid action was tested in vivo using male Swiss-Webster mice. The authors found that DHEA and DHEA-S significantly inhibited induction of hepatic tyrosine aminotransferase activity, although the former was more potent. This inhibition was dose- and time-dependent and was not demonstrable with other steroids. The same inhibitory effect of DHEA was seen with kidney tyrosine aminotransferase induction, as well as with liver and kidney ornithine decarboxylase enzyme activity, another glucocorticoid-induced enzyme. The conclusion is that DHEA acts acutely as an antiglucocorticoid and exerts its effect in different glucocorticoid-sensitive systems.

引用

页码：366 / 371

页数：6

共 34 条

[21] ANDROGENIC AND ESTROGENIC METABOLITES IN SERUM OF MICE FED DEHYDROEPIANDROSTERONE - RELATIONSHIP TO ANTIHYPERGLYCEMIC EFFECTS [J].