SELF-REACTIVE GAMMA-DELTA T-CELLS ARE ELIMINATED IN THE THYMUS

被引：214

作者：

DENT, AL

MATIS, LA

HOOSHMAND, F

WIDACKI, SM

BLUESTONE, JA

HEDRICK, SM

机构：

[1] UNIV CALIF SAN DIEGO, CTR CANC, LA JOLLA, CA 92093 USA

[2] US FDA, CTR BIOL EVALUAT & RES, DIV CYTOKINE BIOL, BETHESDA, MD 20892 USA

[3] UNIV CHICAGO, BEN MAY LAB CANC RES, CHICAGO, IL 60637 USA

来源：

NATURE | 1990年 / 343卷 / 6260期

关键词：

D O I：

10.1038/343714a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genes encoding a γδ T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the Tla locus have been inserted into the mouse germ line. In mice that do not express the Tla-encoded determinant, transgenic γδ T cells are a functional component of the CD4∼CD8∼ 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the Tla-encoded determinant, there are no transgenic γδ T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic γδ T-cell receptor. © 1990 Nature Publishing Group.

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页码：714 / 719

页数：6

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