SELF-REACTIVE GAMMA-DELTA T-CELLS ARE ELIMINATED IN THE THYMUS

被引:214
作者
DENT, AL
MATIS, LA
HOOSHMAND, F
WIDACKI, SM
BLUESTONE, JA
HEDRICK, SM
机构
[1] UNIV CALIF SAN DIEGO, CTR CANC, LA JOLLA, CA 92093 USA
[2] US FDA, CTR BIOL EVALUAT & RES, DIV CYTOKINE BIOL, BETHESDA, MD 20892 USA
[3] UNIV CHICAGO, BEN MAY LAB CANC RES, CHICAGO, IL 60637 USA
关键词
D O I
10.1038/343714a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The genes encoding a γδ T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the Tla locus have been inserted into the mouse germ line. In mice that do not express the Tla-encoded determinant, transgenic γδ T cells are a functional component of the CD4∼CD8∼ 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the Tla-encoded determinant, there are no transgenic γδ T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic γδ T-cell receptor. © 1990 Nature Publishing Group.
引用
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页码:714 / 719
页数:6
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