MUTATION OF GLYCINE-49 TO VALINE IN THE ALPHA-SUBUNIT OF GS RESULTS IN THE CONSTITUTIVE ELEVATION OF CYCLIC-AMP SYNTHESIS

被引:27
作者
WOON, CW
HEASLEY, L
OSAWA, S
JOHNSON, GL
机构
[1] NATL JEWISH CTR IMMUNOL & RESP MED, 1400 JACKSON ST, DENVER, CO 80206 USA
[2] UNIV MASSACHUSETTS, SCH MED, DEPT BIOCHEM, WORCESTER, MA 01655 USA
[3] UNIV COLORADO, SCH MINES, DEPT PHARMACOL, DENVER, CO 80206 USA
关键词
D O I
10.1021/bi00437a006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:4547 / 4551
页数:5
相关论文
共 29 条
[11]  
HEASLEY LE, 1989, MOL PHARMACOL, V35, P331
[12]   CYCLIC AMP-DEPENDENT PROTEIN KINASE - PIVOTAL ROLE IN REGULATION OF ENZYME-INDUCTION AND GROWTH [J].
INSEL, PA ;
BOURNE, HR ;
COFFINO, P ;
TOMKINS, GM .
SCIENCE, 1975, 190 (4217) :896-898
[13]  
JOHNSON GL, 1978, J BIOL CHEM, V253, P7120
[14]  
JONES DT, 1987, J BIOL CHEM, V262, P14241
[15]   HOMOLOGIES IN THE PRIMARY STRUCTURE OF GTP-BINDING PROTEINS - THE NUCLEOTIDE-BINDING SITE OF EF-TU AND P21 [J].
LEBERMAN, R ;
EGNER, U .
EMBO JOURNAL, 1984, 3 (02) :339-341
[16]  
Maniatis T., 1982, MOL CLONING
[17]   FAMILY OF G-PROTEIN ALPHA-CHAINS - AMPHIPATHIC ANALYSIS AND PREDICTED STRUCTURE OF FUNCTIONAL DOMAINS [J].
MASTERS, SB ;
STROUD, RM ;
BOURNE, HR .
PROTEIN ENGINEERING, 1986, 1 (01) :47-54
[18]  
MCGRATH JP, 1984, NATURE, V310, P644, DOI 10.1038/310644a0
[19]   ROLES OF G-PROTEIN SUBUNITS IN TRANSMEMBRANE SIGNALING [J].
NEER, EJ ;
CLAPHAM, DE .
NATURE, 1988, 333 (6169) :129-134
[20]  
ROSKOSKI R, 1983, METHOD ENZYMOL, V99, P3