NEOVASCULOGENESIS - TRIGGERING FACTORS AND POSSIBLE MECHANISMS

被引：47

作者：

BENEZRA, D ^{[1
]}

机构：

[1] NEI, CLIN BRANCH, BETHESDA, MD 20014 USA

来源：

SURVEY OF OPHTHALMOLOGY | 1979年 / 24卷 / 03期

关键词：

chemoattractants; growth factors; indomethacin; keratocytes; leukocytes; mitogens; neovascular attracting factor; neovasculogenesis; prostaglandins;

D O I：

10.1016/0039-6257(79)90020-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The possible regulating mechanism(s) of neovascularization are discussed. Experimental data supporting the view that ocular neovascularization might be triggered by a fundamental metabolic mechanism are presented. Based on his own data and scattered evidence from the literature, the author suggests a model for a possible regulating mechanism of the neovascular process in which the prostaglandins fulfill the role of neovascular mediating substances. Preliminary results demonstrating that indomethacin limits the extent of the neovascular process support this concept and may have a therapeutic implication. Further studies are in progress in order to better understand the pivotal role fulfilled by the prostaglandins in neovasculogenesis. © 1979.

引用

页码：167 / 176

页数：10

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[31] OXYGEN STUDIES IN RETROLENTAL FIBROPLASIA .4. CLINICAL AND EXPERIMENTAL OBSERVATIONS - THE 1ST HOLMES,EDWARD,L. MEMORIAL LECTURE [J].