CHARACTERIZATION OF THE SUBMICROSCOPIC DELETION IN THE SMALL-CELL LUNG-CARCINOMA (SCLC) CELL-LINE U2020

被引：30

作者：

DRABKIN, HA

MENDEZ, MJ

RABBITTS, PH

VARKONY, T

BERGH, J

SCHLESSINGER, J

ERICKSON, P

GEMMILL, RM

机构：

[1] ELEANOR ROOSEVELT INST CANC RES,DENVER,CO

[2] MRC,CLIN ONCOL & RADIOTHERAPEUT,CAMBRIDGE,ENGLAND

[3] UNIV UPPSALA,AKAD SJUKHUSET,DEPT ONCOL,S-75105 UPPSALA,SWEDEN

[4] NYU MED CTR,DEPT PHARMACOL,NEW YORK,NY 10016

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 5卷 / 01期

关键词：

D O I：

10.1002/gcc.2870050110

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The small-cell lung carcinoma cell line U2020 contains a submicroscopic, homozygous deletion that removes a chromosomal segment within 3p13-p14, including the locus D3S3. We have sublocalized 49 additional probes to the 3p13-p14.2 region and have identified 7 new DNA markers that arise from within the U2020 deletion. The estimated size of the deletion, based on marker density, is approximately 4-5 megabases (Mb). Including D3S3, 7 of the 8 markers have been linked by pulsed-field gel (PFG) electrophoresis over an area of approximately 2 Mb. Including the one unlinked marker, PFG analysis accounts for about 3 Mb of the region. The U2020 deletion appears confined to the 3p13-p14.2 region and does not include the candidate tumor suppressor gene, protein-tyrosine phosphatase gamma (PTPG).

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页码：67 / 74

页数：8

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