DEVELOPMENTAL EXPRESSION OF CALMODULIN MESSENGER-RNA AND PROTEIN IN REGIONS OF THE POSTNATAL RAT-BRAIN

被引：17

作者：

BERRY, F ^{[1
]}

BROWN, IR ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT ZOOL,W HILL,ON M1C 1A4,CANADA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1995年 / 42卷 / 05期

关键词：

CALMODULIN MESSENGER-RNA PROTEIN; NORTHERN BLOTTING; WESTERN BLOTTING;

D O I：

10.1002/jnr.490420503

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of calmodulin (CaM) protein and mRNA was analyzed in specific regions of the rat brain during postnatal development. CaM levels in the adult brain were more abundant in the cerebral hemispheres and thalamus compared to brain stem and superior plus inferior colliculus. All brain regions contained higher CaM protein and mRNA levels than in non-neural tissues such as the kidney, During postnatal development of the brain, maximal levels of CaM protein and CaM I mRNAs were attained at day 10 or 15. Protein levels declined thereafter in the adult in all regions except the thalamus. With respect to products of the rat CaM I gene, the 4.0 kb neural transcript demonstrated a pronounced increase during postnatal development, whereas the 1.8 kb message showed little change. (C) 1995 Wiley-Liss, Inc.

引用

页码：613 / 622

页数：10

共 61 条

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