LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE

被引：451

作者：

BROWNING, JL ^{[1
]}

NGAMEK, A ^{[1
]}

LAWTON, P ^{[1
]}

DEMARINIS, J ^{[1
]}

TIZARD, R ^{[1
]}

CHOW, EPC ^{[1
]}

HESSION, C ^{[1
]}

OBRINEGRECO, B ^{[1
]}

FOLEY, SF ^{[1
]}

WARE, CF ^{[1
]}

机构：

[1] UNIV CALIF RIVERSIDE,DIV BIOMED SCI,RIVERSIDE,CA 92521

来源：

CELL | 1993年 / 72卷 / 06期

关键词：

D O I：

10.1016/0092-8674(93)90574-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lymphokine tumor necrosis factor (TNF) has a well-defined role as an inducer of inflammatory responses; however, the function of the structurally related molecule lymphotoxin (LTalpha) is unknown. LTalpha is present on the surface of activated T, B, and LAK cells as a complex with a 33 kd glycoprotein, and cloning of the cDNA encoding the associated protein, called lymphotoxin beta (LTbeta), revealed it to be a type II membrane protein with significant homology to TNF, LTalpha, and the ligand for the CD40 receptor. The gene for LTbeta was found next to the TNF-LT locus in the major histocompatibility complex (MHC), a region of the MHC with possible linkage to autoimmune disease. These observations raise the possibility that a surface LTalpha-LTbeta complex may have a specific role in immune regulation distinct from the functions ascribed to TNF.

引用

页码：847 / 856

页数：10

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