IDENTIFICATION OF LENTIVIRUS TAT FUNCTIONAL DOMAINS THROUGH GENERATION OF EQUINE INFECTIOUS-ANEMIA VIRUS HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAT GENE CHIMERAS

被引：85

作者：

CARROLL, R

MARTARANO, L

DERSE, D

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702

[2] NCI,PRIDYN CORP,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 07期

关键词：

D O I：

10.1128/JVI.65.7.3460-3467.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The structural regions that comprise the functional domains of lentivirus Tat proteins were examined. Chimeric tat genes and chimeric viral promoters were constructed between the distantly related human immunodeficiency virus type 1 (HIV-1) and equine infectious anemia virus (EIAV). These exchange experiments revealed that the EIAV Tat-responsive element recognition domain is formed by two distinct structural regions. Activation domains of both HIV-1 and EIAV Tat contain a conserved core element, but at least HIV-1 Tat requires the presence of additional structural regions. The interchangeable nature of Tat activation domains suggests that these domains act through a common or ubiquitous cellular transcription factor.

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页码：3460 / 3467

页数：8

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共 65 条

[11]

Endo S, 1989, Virus Genes, V3, P99

[12] HIV-1 TAT TRANS-ACTIVATION REQUIRES THE LOOP SEQUENCE WITHIN TAR [J].

FENG, S ;

HOLLAND, EC .

NATURE, 1988, 334 (6178) :165-167

[13] ACTIVITY OF SYNTHETIC PEPTIDES FROM THE TAT PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].

FRANKEL, AD ;

BIANCALANA, S ;

HUDSON, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7397-7401

[14] SEQUENCE OF SIMIAN IMMUNODEFICIENCY VIRUS FROM AFRICAN-GREEN MONKEY, A NEW MEMBER OF THE HIV/SIV GROUP [J].

FUKASAWA, M ;

MIURA, T ;

HASEGAWA, A ;

MORIKAWA, S ;

TSUJIMOTO, H ;

MIKI, K ;

KITAMURA, T ;

HAYAMI, M .

NATURE, 1988, 333 (6172) :457-461

[15] INTERACTIONS OF CELLULAR PROTEINS INVOLVED IN THE TRANSCRIPTIONAL REGULATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS [J].

GARCIA, JA ;

WU, FK ;

MITSUYASU, R ;

GAYNOR, RB .

EMBO JOURNAL, 1987, 6 (12) :3761-3770

[16] HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 LTR TATA AND TAR REGION SEQUENCES REQUIRED FOR TRANSCRIPTIONAL REGULATION [J].

GARCIA, JA ;

HARRICH, D ;

SOULTANAKIS, E ;

WU, F ;

MITSUYASU, R ;

GAYNOR, RB .

EMBO JOURNAL, 1989, 8 (03) :765-778

[17] FUNCTIONAL DOMAINS REQUIRED FOR TAT-INDUCED TRANSCRIPTIONAL ACTIVATION OF THE HIV-1 LONG TERMINAL REPEAT [J].

GARCIA, JA ;

HARRICH, D ;

PEARSON, L ;

MITSUYASU, R ;

GAYNOR, RB .

EMBO JOURNAL, 1988, 7 (10) :3143-3147

[18] NUCLEOTIDE-SEQUENCE AND GENOME ORGANIZATION OF BIOLOGICALLY-ACTIVE PROVIRUSES OF THE BOVINE IMMUNODEFICIENCY-LIKE VIRUS [J].

GARVEY, KJ ;

OBERSTE, MS ;

ELSER, JE ;

BRAUN, MJ ;

GONDA, MA .

VIROLOGY, 1990, 175 (02) :391-409

[19] SPECIFIC BINDING OF A HELA-CELL NUCLEAR-PROTEIN TO RNA SEQUENCES IN THE HUMAN IMMUNODEFICIENCY VIRUS TRANSACTIVATING REGION [J].

GAYNOR, R ;

SOULTANAKIS, E ;

KUWABARA, M ;

GARCIA, J ;

SIGMAN, DS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :4858-4862

[20] NEW TECHNIQUE FOR ASSAY OF INFECTIVITY OF HUMAN ADENOVIRUS 5 DNA [J].

GRAHAM, FL ;

VANDEREB, AJ .

VIROLOGY, 1973, 52 (02) :456-467

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