LONG-TERM SURVIVAL OF XENOGENEIC PANCREATIC-ISLET GRAFTS INDUCED BY CTLA4IG

被引：1148

作者：

LENSCHOW, DJ

ZENG, YJ

THISTLETHWAITE, JR

MONTAG, A

BRADY, W

GIBSON, MG

LINSLEY, PS

BLUESTONE, JA

机构：

[1] UNIV CHICAGO,BEN MAY INST,CHICAGO,IL 60637

[2] UNIV CHICAGO,COMM IMMUNOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT SURG,CHICAGO,IL 60637

[4] UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL 60637

[5] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,SEATTLE,WA 98121

来源：

SCIENCE | 1992年 / 257卷 / 5071期

关键词：

D O I：

10.1126/science.1323143

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antigen-specific T cell activation depends on T cell receptor-ligand interaction and co-stimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immunoglobulin (Ig) G1 Fc region (CTLA4Ig) binds to human and murine B7 with high avidity and blocks T cell activation in vitro. CTLA4Ig therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7+ antigen-presenting cells. In addition, CTLA4Ig induced long-term, donor-specific tolerance, which may have applications to human organic transplantation.

引用

页码：789 / 792

页数：4

共 24 条

[21]

TAN PH, UNPUB

[22] PANCREATIC-ISLET TRANSPLANTATION AFTER UPPER ABDOMINAL EXENTERATION AND LIVER REPLACEMENT [J].