CYTOKINES IN ALZHEIMERS-DISEASE

被引：64

作者：

ALTSTIEL, LD

SPERBER, K

机构：

[1] CUNY MT SINAI SCH MED, FISHBERG NEUROBIOL CTR, NEW YORK, NY 10029 USA

[2] VET ADM MED CTR, DEPT PSYCHIAT, BRONX, NY 10468 USA

[3] CUNY MT SINAI SCH MED, DEPT INTERNAL MED, DIV CLIN IMMUNOL, NEW YORK, NY 10029 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1991年 / 15卷 / 04期

关键词：

BETA-AMYLOID PRECURSOR PROTEIN; CYTOKINE; GLIAL CELLS; INTERLEUKIN-6; INTERLEUKIN-1; NEURONAL CELLS;

D O I：

10.1016/0278-5846(91)90023-T

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Human astrocytoma cells produced biologically active interleukin-6 when treated with a variety of agents including bacterial lipopolysaccharides, viruses, and interleukin-1. 2. Both human recombinant IL-6 and IL-6 produced by stimulated astrocytes promoted differentiation of cultured neuronal cells and reduced survival time in culture. 3. Interleukin-6 and interleukin-1 stimulated the synthesis of the Alzheimer's disease beta-amyloid precursor protein. 4. Cytokines may be involved in stimulation of dystrophic neuritic sprouting, neuronal death, and amyloid deposition noted in the brains of Alzheimer's disease patients.

引用

页码：481 / 495

页数：15

共 33 条

[31] PROTEASE INHIBITOR DOMAIN ENCODED BY AN AMYLOID PROTEIN-PRECURSOR MESSENGER-RNA ASSOCIATED WITH ALZHEIMERS-DISEASE [J].